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KMID : 1130320140570120514
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Korean Journal of Pediatrics
2014 Volume.57 No. 12 p.514 ~ p.519
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BK virus-associated hemorrhagic cystitis after pediatric stem cell transplantation
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Han Seung-Beom
Cho Bin
Kang Jin-Han
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Abstract
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Hemorrhagic cystitis is a common stem cell transplantation-related complication. The incidence of early-onset hemorrhagic cystitis, which is related to the pretransplant conditioning regimen, has decreased with the concomitant use of mesna and hyperhydration. However, late-onset hemorrhagic cystitis, which is usually caused by the BK virus, continues to develop. Although the BK virus is the most common pathogenic microorganism of poststem cell transplantation late-onset hemorrhagic cystitis, pediatricians outside the hemato-oncology and nephrology specialties tend to be unfamiliar with hemorrhagic cystitis and the BK virus. Moreover, no standard guidelines for the early diagnosis and treatment of BK virus-associated hemorrhagic cystitis after stem cell transplantation have been established. Here, we briefly introduce poststem cell transplantation BK virus-associated hemorrhagic cystitis.
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KEYWORD
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Cystitis, Stem cell transplantation, BK virus, Child
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